|
|
dihydroxyacetone_phosphate <=> methylglyoxal + phosphate
|
4.1.2.17
L-fuculose-phosphate aldolase
4.2.3.3
methylglyoxal synthase
5.3.1.1
triose-phosphate isomerase
|
–
–
–
|
BK
|
|
BRENDA:
BR16092
KEGG:
R01016
MetaCyc:
METHGLYSYN-RXN
SABIO-RK:
176
|
|
|
|
D-Lactaldehyde + NAD+ <=> methylglyoxal + NADH + H+
|
1.1.1.78
methylglyoxal reductase (NADH)
1.1.1.79
glyoxylate reductase (NADP+)
|
–
–
|
MK
|
|
BRENDA:
BR22616
KEGG:
R02527
MetaCyc:
D-LACTALDEHYDE-DEHYDROGENASE-RXN
|
|
|
|
Pentane-2,4-dione + O2 <=> H+ + acetate + methylglyoxal
|
1.13.11.50
acetylacetone-cleaving enzyme
|
–
|
|
|
BRENDA:
BR47366
KEGG:
R07183
MetaCyc:
RXN-12017
|
|
|
|
L-lactaldehyde + NADP+ <=> methylglyoxal + NADPH + H+
|
1.1.1.156
glycerol 2-dehydrogenase (NADP+)
1.1.1.2
alcohol dehydrogenase (NADP+)
1.1.1.21
aldose reductase
1.1.1.283
methylglyoxal reductase (NADPH)
1.1.1.71
alcohol dehydrogenase [NAD(P)+]
1.1.1.72
glycerol dehydrogenase (NADP+)
1.1.1.78
methylglyoxal reductase (NADH)
1.2.1.49
2-oxoaldehyde dehydrogenase (NADP+)
|
–
–
–
–
–
–
–
–
|
BMK
|
|
BRENDA:
BR48480;
BS139557
KEGG:
R02260
MetaCyc:
1.1.1.283-RXN
SABIO-RK:
550;
9214
|
|
|
|
D-lactate + H+ <=> methylglyoxal + H2O
|
3.5.1.124
protein deglycase
4.2.1.130
D-lactate dehydratase
|
–
–
|
BK
|
|
BRENDA:
BR49777
KEGG:
R09796
MetaCyc:
GLYOXIII-RXN
|
|
|
|
methylglyoxal + D-fructose_1,6-bisphosphate <=> D-glyceraldehyde_3-phosphate + 1-deoxy-D-threo-hexo-2,5-diulose_6-phosphate
|
2.2.1.11
6-deoxy-5-ketofructose 1-phosphate synthase
|
–
|
BMK
|
|
BRENDA:
BR50117
KEGG:
R10049
MetaCyc:
RXN-10053
|
|
|
|
methylglyoxal + D-Fructose_1-phosphate <=> D-glyceraldehyde + 1-deoxy-D-threo-hexo-2,5-diulose_6-phosphate
|
2.2.1.11
6-deoxy-5-ketofructose 1-phosphate synthase
|
–
|
K
|
|
BRENDA:
BR50118
KEGG:
R10050
MetaCyc:
RXN-13144
|
|
|
|
methylglyoxal + O2 + H2O <=> pyruvate + H2O2 + H+
|
1.2.3.15
(methyl)glyoxal oxidase
|
–
|
|
|
BRENDA:
BR51649
KEGG:
R11352
MetaCyc:
RXN-17510
|
|
|
|
enolaldehyde <=> methylglyoxal
|
0.0.0.0
|
–
|
BM
|
|
BRENDA:
BR52893
MetaCyc:
RXN-10054
|
|
|
|
S-D-lactoylglutathione <=> methylglyoxal + glutathione
|
4.4.1.5
lactoylglutathione lyase
|
–
|
BMK
|
|
BRENDA:
BR6441
KEGG:
R02530
MetaCyc:
GLYOXI-RXN
SABIO-RK:
177
|
|
|
|
Hydroxyacetone + NADP+ <=> H+ + methylglyoxal + NADPH
|
1.1.1
1.1.1.1
alcohol dehydrogenase
1.1.1.153
sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)
1.1.1.2
alcohol dehydrogenase (NADP+)
1.1.1.21
aldose reductase
1.1.1.72
glycerol dehydrogenase (NADP+)
1.3.1.20
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
|
–
–
–
–
–
–
–
|
MK
|
|
BRENDA:
BS188596
KEGG:
R02528
MetaCyc:
RXN0-4281
SABIO-RK:
2450
|
|
|
|
H+ + methylglyoxal + NADH <=> Hydroxyacetone + NAD+
|
1.1.1
1.1.1.1
alcohol dehydrogenase
1.1.1.21
aldose reductase
1.1.1.75
(R)-aminopropanol dehydrogenase
|
–
–
–
–
|
K
|
|
BRENDA:
BS188635
KEGG:
R10718
MetaCyc:
RXN0-5213
SABIO-RK:
9806
|
|
|
|
methylglyoxal + NAD+ + H2O <=> H+ + pyruvate + NADH
|
1.2.1.19
aminobutyraldehyde dehydrogenase
1.2.1.22
lactaldehyde dehydrogenase
1.2.1.23
2-oxoaldehyde dehydrogenase (NAD+)
1.2.1.3
aldehyde dehydrogenase (NAD+)
1.2.1.46
formaldehyde dehydrogenase
1.2.1.8
betaine-aldehyde dehydrogenase
|
–
–
–
–
–
–
|
MK
|
|
BRENDA:
BS189163
KEGG:
R00203
MetaCyc:
METHYL-GLYOXAL-DEHYDROG-RXN
SABIO-RK:
520
|
|
|
|
methylglyoxal + NADP+ + H2O <=> H+ + pyruvate + NADPH
|
1.2.1.19
aminobutyraldehyde dehydrogenase
1.2.1.23
2-oxoaldehyde dehydrogenase (NAD+)
1.2.1.49
2-oxoaldehyde dehydrogenase (NADP+)
|
–
–
–
|
MK
|
|
BRENDA:
BS189258
KEGG:
R00205
MetaCyc:
RXN-8639
SABIO-RK:
521
|
|
|
|
aminoacetone + H2O + O2 <=> methylglyoxal + NH3 + H2O2
|
1.4.3.21
primary-amine oxidase
1.4.3.4
monoamine oxidase
|
–
–
|
BMK
|
|
BRENDA:
BS407108
KEGG:
R02529
MetaCyc:
AMACETOXID-RXN
|
|
|
|
methylglyoxal + NADH <=> lactaldehyde + NAD+
|
1.1.1.1
alcohol dehydrogenase
1.1.1.21
aldose reductase
1.1.1.6
glycerol dehydrogenase
1.1.1.78
methylglyoxal reductase (NADH)
|
–
–
–
–
|
|
|
BRENDA:
BS353234
KEGG:
R02531
SABIO-RK:
553
|
|
|
|
methylglyoxal + glutathione + NAD+ <=> S-pyruvylglutathione + NADH
|
1.1.1.284
S-(hydroxymethyl)glutathione dehydrogenase
|
–
|
|
|
BRENDA:
BS189072
SABIO-RK:
12381
|
|
|
|
L-lactaldehyde + NAD+ <=> methylglyoxal + NADH + H+
|
1.1.1.6
glycerol dehydrogenase
|
–
|
K
|
|
KEGG:
R10715
|
|
|
|
L-lactaldehyde + coenzyme_F420 <=> methylglyoxal + reduced_coenzyme_F420
|
1.1.98.5
secondary-alcohol dehydrogenase (coenzyme-F420)
|
–
|
M
|
|
MetaCyc:
RXN-10064
|
|
|
|
1,1-dihydroxypropan-2-one <=> methylglyoxal + H2O
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-17626
|
|
|
|
Hydroxyacetone + O2 + reduced_[NADPH-hemoprotein_reductase] <=> methylglyoxal + H2O + oxidized_[NADPH-hemoprotein_reductase]
|
1.14.14.1
unspecific monooxygenase
|
–
|
|
|
MetaCyc:
RXN-17627
|
|
|
|
methylglyoxal + filaggrin_L-Arg <=> an_Nomega-(1-hydroxy-2-oxopropyl)-[protein]-L-arginine
|
not assigned
|
–
|
|
|
MetaCyc:
RXN-17629
|
|
|
|
methylglyoxal + a_[protein]-L-tyrosine <=> an_N6-(1-hydroxy-2-oxopropyl)-[protein]-L-lysine + H+
|
not assigned
|
–
|
|
|
MetaCyc:
RXN-17631
|
|
|
|
methylglyoxal + protein <=> an_S-(1-hydroxy-2-oxopropyl)-[protein]-L-cysteine
|
not assigned
|
–
|
|
|
MetaCyc:
RXN-17633
|
|
|
|
methylglyoxal + H2O + O2 <=> methyl_glyoxylate + H2O2
|
1.2.3.15
(methyl)glyoxal oxidase
|
–
|
|
|
BRENDA:
BS436509
|
|
|
|
Hydroxyacetone + O2 <=> methylglyoxal + H2O2
|
1.1.3.9
galactose oxidase
|
–
|
|
|
BRENDA:
BS257703
|
|
|
|
1,2-propanediol + O2 <=> methylglyoxal + H2O2
|
1.1.3.18
secondary-alcohol oxidase
|
–
|
|
|
BRENDA:
BS230946
|
|
|
|
trypanothione + 2 methylglyoxal <=> 5,5''-bi((R)-lactoyl)trypanothione
|
4.4.1.5
lactoylglutathione lyase
|
–
|
|
|
BRENDA:
BS429415
|
|
|
|
2-oxoisovalerate + methylglyoxal <=> (S)-3-hydroxy-5-methylhexane-2,4-dione + CO2
|
2.2.1.5
2-hydroxy-3-oxoadipate synthase
|
–
|
|
|
BRENDA:
BS435052
|
|
|
|
2-Oxopentanoate + methylglyoxal <=> (S)-3-hydroxyheptane-2,4-dione + CO2
|
2.2.1.5
2-hydroxy-3-oxoadipate synthase
|
–
|
|
|
BRENDA:
BS435061
|
|
|
|
malondialdehyde <=> methylglyoxal
|
5.3.1.9
glucose-6-phosphate isomerase
|
–
|
|
|
BRENDA:
BS380052
|
|
|
|
methylglyoxal + ferricyanide <=> pyruvate + ferrocyanide + H+
|
1.2.5.2
aldehyde dehydrogenase (quinone)
|
–
|
|
|
BRENDA:
BS432129
|
|
|
|
methylglyoxal + H2O + propionaldehyde <=> pyruvate + 1-propanol
|
1.2.98.1
formaldehyde dismutase
|
–
|
|
|
BRENDA:
BS258330
|
|
|
|
methylglyoxal + H2O <=> pyruvate + 1,2-propanediol
|
1.2.98.1
formaldehyde dismutase
|
–
|
|
|
BRENDA:
BS258328
|
|
|
|
methylglyoxal + NADH <=> L-lactaldehyde
|
1.1.1.185
L-glycol dehydrogenase
|
–
|
|
|
BRENDA:
BS187455
|
|
|
|
2-oxoglutarate + methylglyoxal <=> (R)-5-hydroxy-4,6-dioxoheptanoic_acid + CO2
|
2.2.1.5
2-hydroxy-3-oxoadipate synthase
|
–
|
|
|
BRENDA:
BS435047
|
|
|
|
trypanothione + methylglyoxal <=> S,S''-bis((R)-lactoyl)trypanothione
|
4.4.1.5
lactoylglutathione lyase
|
–
|
|
|
BRENDA:
BS382771
|
|
|
|
3-Chloro-1,2-propanediol + NAD+ <=> (R)-3-chloropropane-1,2-diol + methylglyoxal + acetate + Cl- + formate + NADH
|
3.8.1.5
haloalkane dehalogenase
|
–
|
|
|
BRENDA:
BS375479
|
|
|
|
pyruvylglutathione + NADH + H+ <=> methylglyoxal + NAD+
|
1.1.1.284
S-(hydroxymethyl)glutathione dehydrogenase
|
–
|
|
|
BRENDA:
BS451029
|
|
|
|
1,2-propanediol + NAD+ <=> methylglyoxal + NADH
|
1.1.1.245
cyclohexanol dehydrogenase
|
–
|
|
|
BRENDA:
BS187960
|
|
|
|
glutathione + methylglyoxal <=> S-Lactoylglutathione
|
4.4.1.5
lactoylglutathione lyase
|
–
|
|
|
BRENDA:
BS37509
|
|
|
|
methylglyoxal + NADPH <=> lactaldehyde + NADPH
|
1.1.1.71
alcohol dehydrogenase [NAD(P)+]
|
–
|
|
|
BRENDA:
BS188576
|
|
|
|
trypanothione + methylglyoxal <=> S-D-lactoylglutathione
|
4.4.1.5
lactoylglutathione lyase
|
–
|
|
|
BRENDA:
BS429416
|
|
|
|
methylglyoxal + NADPH + H+ <=> (R)-lactataldehyde + NADP+
|
1.1.1.283
methylglyoxal reductase (NADPH)
1.1.1.78
methylglyoxal reductase (NADH)
|
–
–
|
|
|
BRENDA:
BS373842
|
|
|
|
glutathione_ethyl_ester + methylglyoxal <=> S-lactoylglutathionyl_ethyl_ester
|
4.4.1.5
lactoylglutathione lyase
|
–
|
|
|
BRENDA:
BS453558
|
|
|
|
glutathione_isopropyl_ester + methylglyoxal <=> S-lactoylglutathionyl_isopropyl_ester
|
4.4.1.5
lactoylglutathione lyase
|
–
|
|
|
BRENDA:
BS453559
|
|
|
|
S-D-lactoyltrypanothione <=> methylglyoxal + trypanothione
|
4.4.1.5
lactoylglutathione lyase
|
–
|
|
|
BRENDA:
BS382772
|
|
|
|
methylglyoxal + veratryl_alcohol <=> Hydroxyacetone + 3,4-dimethoxybenzaldehyde
|
1.1.99.36
alcohol dehydrogenase (nicotinoprotein)
|
–
|
|
|
SABIO-RK:
14285
|
|
|
|
1,2-propanediol + N,N-dimethyl-4-nitrosoaniline <=> methylglyoxal + 4-(hydroxylamino)-N,N-dimethylaniline
|
1.1.99.36
alcohol dehydrogenase (nicotinoprotein)
|
–
|
|
|
SABIO-RK:
14273
|
|
|
|
methylglyoxal + ATP <=> Methylglyoxal_phosphate + ADP
|
2.7.1.29
glycerone kinase
|
–
|
|
|
SABIO-RK:
15485
|
|